- 1. Quick Start guides
- 1.1. Constructing bedMethyl tables
- 1.1.1. Migrating to v0.6.0
- 1.2. Make hemi-methylation bedMethyl tables
- 1.3. Updating and adjusting MM tags
- 1.4. Inspecting base modification probabilities
- 1.5. Summarizing a modBAM
- 1.6. Calculating modification statistics in regions
- 1.7. Calling mods in a modBAM
- 1.8. Removing modification calls at the ends of reads
- 1.9. Repair MM/ML tags on trimmed reads
- 1.10. Working with sequence motifs
- 1.10.1. Making a motif BED file
- 1.10.2. Find highly modified motif sequences
- 1.10.3. Evaluate and refine a table of known motifs
- 1.10.4. Structured logging schema
- 1.11. Extracting read information to a table
- 1.12. Investigating patterns with localise
- 1.13. Perform differential methylation scoring
- 1.14. Validate ground truth results
- 1.15. Calculating methylation entropy
- 1.16. Narrow output to specific positions
- 1.17. Manipulate bedMethyl files
- 1.18. Check modified base tags
- 1.19. Find regions of accessible chromatin
- 2. Extended subcommand help
- 3. Troubleshooting
- 4. Frequently asked questions
- 5. Current limitations
- 6. Performance considerations
- 7. Algorithm details
- 7.1. Pass/fail base modification calls
- 7.1.1. Threshold examples
- 7.1.2. Numeric details
- 7.2. DMR model and scoring details
- 7.3. Ignoring and combining calls